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Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover
Li Di
(Illustrated by)
·
Edward H. Kerns
(Illustrated by)
·
Wiley
· Hardcover
Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover - Di, Li ; Kerns, Edward H.
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Synopsis "Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs Format: Hardcover"
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. - Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects - Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies - Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes - Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) - Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
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All books in our catalog are Original.
The book is written in English.
The binding of this edition is Hardcover.
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