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Concomitant Tuberculosis Infection in HIV-positive Patients
Hirdesh Kumari Gupta
(Author)
·
Abhishek Mehta
(Author)
·
Grin Verlag
· Paperback
Concomitant Tuberculosis Infection in HIV-positive Patients - Gupta, Hirdesh Kumari ; Mehta, Abhishek
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Synopsis "Concomitant Tuberculosis Infection in HIV-positive Patients"
Document from the year 2015 in the subject Biology - Micro- and Molecular Biology, grade: A, course: Dept. of Microbiology, MLB Medical college, Jhansi, language: English, abstract: Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are two major public health problems in many parts of the world, particularly in many developing countries. TB is the most common opportunistic disease and cause of the death for those infected with HIV. Diagnosis of TB in HIV infected patients may be delayed because of atypical clinical presentation and involvement of inaccessible sites and low sputum smear positivity. Further, there has been an increase in rates of drug resistant tuberculosis, including multi-drug (MDR-TB) and extensively drug resistant TB (XDR-TB), which are difficult to treat and contribute to increased morbidity and mortality. TB is the most common serious opportunistic infection in HIV positive patients and is the manifestation of AIDS in more than 50% of cases in developing countries. TB shortens the survival of patients afflicted with HIV infection, may accelerate the progression of HIV, and is the cause of death in one third of people with AIDS worldwide. While HIV and TB can individually be the major causes for public health threats, the combination of the two has proven to have a far greater impact on the epidemiologic progression and consequently on the global health scene. Although the increased access to highly active antiretroviral therapy (HAART) has led to a reduction in HIV-associated opportunistic infections and hence mortality, but the concurrent management of HIV/TB co-infection remains a serious challenge to the health care delivery system. Discussion on the mechanisms produced by infectious cofactors with impact on disease pathology could shed light on how to design potential interventions that could decelerate disease progression. It is the need of the hour to design strategies against HIV-TB co-infection. Thi
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