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Handbook of LC-MS Bioanalysis: Best Practices, Experimental Protocols, and Regulations
Jie Zhang
(Illustrated by)
·
Wenkui Li
(Illustrated by)
·
Francis L. S. Tse
(Illustrated by)
·
Wiley
· Hardcover
Handbook of LC-MS Bioanalysis: Best Practices, Experimental Protocols, and Regulations - Li, Wenkui ; Zhang, Jie ; Tse, Francis L. S.
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Synopsis "Handbook of LC-MS Bioanalysis: Best Practices, Experimental Protocols, and Regulations"
Consolidates the information LC-MS bioanalytical scientistsneed to analyze small molecules and macromoleculesThe field of bioanalysis has advanced rapidly, propelled by newapproaches for developing bioanalytical methods, new liquidchromatographic (LC) techniques, and new mass spectrometric (MS)instruments. Moreover, there are a host of guidelines andregulations designed to ensure the quality of bioanalyticalresults.Presenting the best practices, experimental protocols, and thelatest understanding of regulations, this book offers acomprehensive review of LC-MS bioanalysis of small molecules andmacromolecules. It not only addresses the needs of bioanalyticalscientists working on routine projects, but also explores advancedand emerging technologies such as high-resolution mass spectrometryand dried blood spot microsampling.Handbook of LC-MS Bioanalysis features contributions froman international team of leading bioanalytical scientists. Theircontributions reflect a review of the latest findings, practices,and regulations as well as their own firsthand analyticallaboratory experience. The book thoroughly examines:Fundamentals of LC-MS bioanalysis in drug discovery, drugdevelopment, and therapeutic drug monitoringThe current understanding of regulations governing LC-MSbioanalysisBest practices and detailed technical instructions for LC-MSbioanalysis method development, validation, and stabilityassessment of analyte(s) of interestExperimental guidelines and protocols for quantitative LC-MSbioanalysis of challenging molecules, including pro-drugs, acylglucuronides, N-oxides, reactive compounds, and photosensitive andautooxidative compoundsWith its focus on current bioanalytical practice, Handbook ofLC-MS Bioanalysis enables bioanalytical scientists to developand validate robust LC-MS assay methods, all in compliance withcurrent regulations and standards.
