Share
molecular biology of the parathyroid
Tally Naveh-Many
(Illustrated by)
·
Springer
· Paperback
molecular biology of the parathyroid - Naveh-Many, Tally
Choose the list to add your product or create one New List
✓ Product added successfully to the Wishlist.
Go to My Wishlists
Origin: U.S.A.
(Import costs included in the price)
It will be shipped from our warehouse between
Tuesday, June 25 and
Thursday, July 11.
You will receive it anywhere in United Kingdom between 1 and 3 business days after shipment.
Synopsis "molecular biology of the parathyroid"
aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu- M lar calcium levels, by acting on bone, kidney and intestine. The recent intro- duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper- plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres- sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha- nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para- thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex- pression to its intracellular processing and the sequences in the gene control- ling its transcription as well as those regulating mRNA processing, stability and translation are described.
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
- 0% (0)
All books in our catalog are Original.
The book is written in English.
The binding of this edition is Paperback.
✓ Producto agregado correctamente al carro, Ir a Pagar.
