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portada nicotinic acetylcholine receptors in the nervous system
Type
Physical Book
Publisher
Year
2011
Language
English
Pages
424
Format
Paperback
Dimensions
24.4 x 17.0 x 2.3 cm
Weight
0.71 kg.
ISBN
364274169x
ISBN13
9783642741692

nicotinic acetylcholine receptors in the nervous system

Francesco Clementi (Illustrated by) · Cecilia Gotti (Illustrated by) · Emanuele Sher (Illustrated by) · Springer · Paperback

nicotinic acetylcholine receptors in the nervous system - Clementi, Francesco ; Gotti, Cecilia ; Sher, Emanuele

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Synopsis "nicotinic acetylcholine receptors in the nervous system"

The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled by acetylcholine. It is a key molecule in the chemical communication between nerve cells and between nerve cell and muscle. The structure and function of muscular nicotinic receptors have been unraveled in recent years and its beauty and mysteries were reviewed in the Santorini NATO ARW organized by Dr. Maelicke in 1986. The neat, linear structure of this molecule and its conservation throughout evolution, from bacteria to humans, have led to the suggestion that it has reached the optimal structure for performing its function. But when scientists began to look at the nicotinic receptor in the nervous system, they found several surprises. From the beginning, pharmacological and physiological experiments, have made it clear that the functional characteristics of neuronal nicotinic receptors are substantially different from those of muscle receptors. Furthermore, recent sophisticated techniques such as patch clamp and gene cloning have revealed that the nicotinic receptor in the nervous system is not a single molecule but (although there are some important exceptions) a large family of similar molecules, which have in common the property of binding nicotinic agonists or antagonists. Over the last few years, the physiological implications of nicotinic receptors have been reevaluated on the basis of more precise behavioural and pharmacological techniques. Moreover, the involvement of nicotinic receptors in degenerative pathologies of the eNS, such as Parkinson's and Alzheimer's disease, has also been discovered very recently.

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