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A Handbook For Dna - Encoded Chemistry: Theory And Applications For Exploring Chemical Space And Drug Discovery
Robert A. Goodnow Jr
Synopsis "A Handbook For Dna - Encoded Chemistry: Theory And Applications For Exploring Chemical Space And Drug Discovery"
This Book Comprehensively Describes The Development And Practice Of Dna - Encoded Library Synthesis Technology. Important Aspects Are Expertly Detailed, Including Dna - Compatible Chemistry, Dna - Encoded Library Synthesis, Design Of Chemical Genes, Analytical Methods For Small Molecule - Dna Libraries, Selection Methods, Hit Identification, And Dna - Directed Chemistry. Despite Many Publications On Various Results From Laboratories Specializing In The Synthesis Of Hit Finding Of Dna - Encoded Chemistry That Have Been Published Since 1992, There Has Been No Technical Handbook Offering This Level Of Detail. This Book Begins With A Brief Primer Of Oligonucleotide Concepts Necessary For The Dna - Encoded Chemistry Practitioner. A Brief History Of The Development Of Combinatorial Chemistry Gives A Necessary Perspective To The Emergence Of Dna - Encoded Chemistry Methods. The Authors Have Reformatted Published Experimental Procedures For The Synthesis And Analysis Of A Dna - Encoded Combinatorial Chemistry Library In An Easy To Reproduce Manner. A Method For The Design And Analysis Of A 100 Million Compound Library Is Also Described. Together, The Chapters Detail An Approach To Drug Discovery That Differs From More Classical Approaches Such As High Throughput Screening, Offering Attractive Alternatives To Resource - And Cost - Intensive Corporate Chemical Libraries For Screening And Lead Discovery. An Analysis Of The Costs Of Creating Such A Hit And Lead Generation Approach Highlights The Economic Advantage Of This Approach For Exploration Of Chemistry Space
