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portada chromosomal translocations and oncogenic transcription factors
Type
Physical Book
Publisher
Year
2011
Language
English
Pages
166
Format
Paperback
Dimensions
23.4 x 15.6 x 1.0 cm
Weight
0.27 kg.
ISBN
3642644244
ISBN13
9783642644245

chromosomal translocations and oncogenic transcription factors

Peter K. Vogt (Illustrated by) · Frank J. III Rauscher (Illustrated by) · Springer · Paperback

chromosomal translocations and oncogenic transcription factors - Rauscher, Frank J. III ; Vogt, Peter K.

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Synopsis "chromosomal translocations and oncogenic transcription factors"

Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcription factors which result in diverse neoplastic processes. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type. The book provides inspiration for exploiting these tumor-specific alterations as diagnostic, prognostic tools, or as selective therapeutic targets.

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