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portada transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy
Type
Physical Book
Preface by
Illustrated by
Publisher
Year
2010
Language
Inglés
Pages
786
Format
Paperback
Dimensions
25.4 x 17.8 x 4.1 cm
Weight
1.38 kg.
ISBN
1617377368
ISBN13
9781617377365

transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy

C. -H Heldin (Preface by) · Sonia B. Jakowlew (Illustrated by) · Humana · Paperback

transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy - Heldin, C. -H ; Jakowlew, Sonia B.

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Synopsis "transforming growth factor-beta in cancer therapy, volume ii: cancer treatment and therapy"

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.

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