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portada Adaptive Design Methods in Clinical Trials (Chapman & Hall
Type
Physical Book
Publisher
Language
English
Pages
374
Format
Paperback
ISBN13
9781032477602
Edition No.
2

Adaptive Design Methods in Clinical Trials (Chapman & Hall

Shein-Chung Chow; Mark Chang (Author) · Crc Pr Inc · Paperback

Adaptive Design Methods in Clinical Trials (Chapman & Hall - Shein-Chung Chow; Mark Chang

Physical Book

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Synopsis "Adaptive Design Methods in Clinical Trials (Chapman & Hall"

With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology.New to the Second EditionAlong with revisions throughout the text, this edition significantly updates the chapters on protocol amendment and clinical trial simulation to incorporate the latest changes. It also includes five entirely new chapters on two-stage adaptive design, biomarker adaptive trials, target clinical trials, sample size and power estimation, and regulatory perspectives.Following in the tradition of its acclaimed predecessor, this second edition continues to offer an up-to-date resource for clinical scientists and researchers in academia, regulatory agencies, and the pharmaceutical industry. Written in an intuitive style at a basic mathematical and statistical level, the book maintains its practical approach with an emphasis on concepts via numerous examples and illustrations.

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