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portada Developmental Toxicology
Type
Physical Book
Publisher
Language
English
Pages
408
Format
Hardcover
Dimensions
23.1 x 15.5 x 2.3 cm
Weight
0.66 kg.
ISBN
1420054376
ISBN13
9781420054378
Edition No.
0003

Developmental Toxicology

Deborah K. Hansen (Author) · Barbara D. Abbott (Author) · CRC Press · Hardcover

Developmental Toxicology - Hansen, Deborah K. ; Abbott, Barbara D.

Physical Book

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Synopsis "Developmental Toxicology"

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs.The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed.Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes

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