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From Globular Proteins to Amyloids (Commonwealth and International Library)
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Synopsis "From Globular Proteins to Amyloids (Commonwealth and International Library)"
The phenomenon of amyloidosis has attracted the attention of numerous researchers for two main reasons: (1) it involves unexpected changes in protein conformation (without chemical intervention) and (2) has practical implications, such as elucidating the mechanisms which drive neurodegenerative diseases carries. In particular, understanding the process of amyloidosis is a fundamental prerequisite in the search for new, effective drugs and therapies targeting the key area of neurodegenerative diseases. The book proposes a model and a mechanism which explain protein misfolding. The concepts presented are based on a model originally intended to show how proteins attain their native conformations. The model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process. It also identifies progressive changes which occur in native proteins, leading to the emergence of amyloid aggregations.The book introduces basic rules for protein folding as well as conditions which result in misfoldingThe novelty of the presented research lies in treating the aqueous environment as a continuum rather than a set of individual water molecules (i.e. the classic representation)The effect of the environment is modelled as an external force field which affects the folding process at each stageProvides practical applications in helping the prevention of amyloidosis and improving drug design
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All books in our catalog are Original.
The book is written in English.
The binding of this edition is Paperback.
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