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portada Role of Interleukin 23 in the Pathogenesis of Psoriasis
Type
Physical Book
Language
English
Pages
152
Format
Paperback
Dimensions
22.9 x 15.2 x 0.9 cm
Weight
0.23 kg.
ISBN13
9786202353854

Role of Interleukin 23 in the Pathogenesis of Psoriasis

Amel Raouf (Author) · Noor Publishing · Paperback

Role of Interleukin 23 in the Pathogenesis of Psoriasis - Raouf, Amel

New Book

£ 58.86

  • Condition: New
Origin: U.S.A. (Import costs included in the price)
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Synopsis "Role of Interleukin 23 in the Pathogenesis of Psoriasis"

Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation, increased angiogenesis and inflammation. The pathogenesis of psoriasis is still unclear. Interleukin 23 (IL 23) plays a role in T cell immune responses. IL 23 is produced by activated dendritic cells, macrophages and keratinocytes. IL-23 amplifies and stabilizes a new CD4 (+) T-cell subset, Th17 producing IL-17. Th17 cells are highly pathogenic and lead to the development of inflammation and severe autoimmunity. Twenty patients with psoriasis vulgaris in the age group (17-60) years were included in this study. Also 20 normal volunteers were included. Two punch biopsies were taken from every patient one from the lesion and one from non lesional area. One puch biopsy was taken from each control. Il 23 was measured using a real time PCR. Our data revealed that the level of IL 23, in the patient group, was higher in lesional areas than in non lesional areas and this difference was statistically significant (p value

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