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portada phosphoinositides i
Type
Physical Book
Publisher
Language
English
Format
Hardcover
Dimensions
23.4 x 15.7 x 2.5 cm
Weight
0.66 kg.
ISBN
940073011x
ISBN13
9789400730113

phosphoinositides i

Tamas Balla (Illustrated by) · Matthias Wymann (Illustrated by) · John D. York (Illustrated by) · Springer · Hardcover

phosphoinositides i - Balla, Tamas ; Wymann, Matthias ; York, John D.

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Synopsis "phosphoinositides i"

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

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