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portada Ricin Toxins
Type
Physical Book
Publisher
Year
2020
Language
English
Pages
154
Format
Paperback
ISBN13
9783039285129

Ricin Toxins

New Book

£ 44.90

  • Condition: New
Origin: U.S.A. (Import costs included in the price)
It will be shipped from our warehouse between Tuesday, June 04 and Thursday, June 20.
You will receive it anywhere in United Kingdom between 1 and 3 business days after shipment.

Synopsis "Ricin Toxins"

The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat. Tons of ricin are produced annually worldwide as a by-product of castor oil, leading to exposure. Currently, there is no proven safe treatment for ricin intoxication. Ricin consists of an active A subunit (RTA) covalently linked to a cell binding B subunit (RTB). RTA depurinates a universally conserved adenine in the sarcin-ricin loop (SRL) of the large rRNA and inhibits protein synthesis. RTA-antibody complexes have been explored as immunotoxins against cancer cells. The articles published in this book address the history of ricin research, how ricin enters cells and traffics to the ribosome, how it inactivates ribosomes, how it induces inflammatory signaling pathways and programmed cell death, the design of therapies against ricin intoxication, and innovative assays for ricin detection.

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