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portada structure-based drug discovery
Type
Physical Book
Publisher
Year
2010
Language
English
Pages
250
Format
Paperback
Dimensions
23.4 x 15.6 x 1.4 cm
Weight
0.37 kg.
ISBN
9048171237
ISBN13
9789048171231

structure-based drug discovery

Andrew R. Leach (Illustrated by) · Harren Jhoti (Illustrated by) · Springer · Paperback

structure-based drug discovery - Jhoti, Harren ; Leach, Andrew R.

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Synopsis "structure-based drug discovery"

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications. This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology.

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